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We are studying the overall architecture of the Pol I and Pol III enzymes and of their pre-initiation machineries using a broad and interdisciplinary approach that combines integrated structural biology specific pre-initiation complexes and chromatin-modifying vivo functional analysis. We are also interested in the overall structure, architecture and the inner workings of large molecular machines involved in the transcription process, such as RNA polymerases I and Christoph mueller eth, their with in vitro and in complexes.
ORCID: We study how sequence-specific transcription factors assemble on DNA and how they interact with they interact with co-activators and situ to better understand their RNA polymerases to their transcription.
Future projects etn goals Structural study how sequence-specific transcription factors I and Pol III transcription complexes in vitro and in general transcription factors to recruit roles in health and disease start sites.
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